The main protagonist is professional treasure hunter Nathan Drake, who claims to be a descendent of English explorer Francis Drake. The other primary characters are Victor "Sully" Sullivan, a former US Navy officer who becomes Nate's mentor and father figure; investigative journalist Elena Fisher, who becomes Nate's romantic partner; and Chloe Frazer, a reckless adventurer who serves as a foil to Elena.

Tom Holland has said the film will be a prequel and will draw inspiration from Uncharted 4: A Thief's End.

Nate and his brother Sam travel to Panama to hunt for the lost treasure of a pirate named Henry Avery, and they ally themselves with rival treasure hunter and businessman Rafe Adler.

Fifteen years after the events of Uncharted 3: Drake's Deception, Sam shows up to see Nate, who is now married to Elena, and persuades his brother to assist him on one last treasure hunt.

Sam's life is at stake: either the brothers find Avery's treasure, or Sam will be killed by drug lord Hector Alcázar. The storyline also includes more information about the Drake brothers' backstory: their historian mother had a theory about the descendants of Drake, and when they got into trouble with the law, the brothers changed their last name to Drake in her honor.

Several of those story elements seem to have been preserved in Fleischer's film, although the trailer mentions Ferdinand Magellan's explorations (rather than Avery's pirate treasure) and a legendary lost treasure possibly associated with the Portuguese explorer.

Based on one of the best-selling, most critically acclaimed video game series of all time, Uncharted introduces audiences to the young street-smart Nathan Drake (Tom Holland) and showcases his first treasure hunting adventure with wisecracking partner Victor "Sully" Sullivan (Mark Wahlberg).

Fun fact: Wahlberg was originally in the running to star as Nathan Drake, but the film took so long to make, he aged out of the role.