NIH awards $38 million to improve utility of polygenic risk scores in diverse populations - EurekAlert
Jun 16, 2021 1 min, 25 secs

IMAGE: Research studies are using polygenic risk scores to determine a person's inherited risk for certain diseases.

The National Institutes of Health (NIH) will fund grants totaling $38 million over five years to develop methods that will improve the way that polygenic risk scores can be used to predict disease in diverse communities.

Polygenic risk scores, often referred to as PRS, are a genetic estimate of a person's risk for specific diseases.

Researchers and clinicians calculate polygenic risk scores by comparing the genomic data of people with and without a particular disease.

Research shows that early approaches to calculating polygenic risk scores, which were developed using data from mostly European ancestry populations, are not effective when used in diverse populations.

The new consortium will pool genomic information from existing and new datasets to develop and evaluate the methods used for calculating polygenic risk scores for specific diseases, with an emphasis on studying people from different ancestries.

Researchers have used available large-scale genomic datasets to develop the ability to calculate polygenic risk scores for numerous conditions, such as coronary heart disease and diabetes, and to identify people who are at high risk.

"One of our biggest concerns is that data used to calculate polygenic risk scores do not include sufficient numbers of individuals from diverse populations, falling short of effectively predicting disease risk in non-European populations," said Teri Manolio, M.D., Ph.D., director of the Division of Genomic Medicine at NHGRI.

"AnVIL will foster collaborations within the consortium and the biomedical research community by providing a shared analysis and computing environment to develop and evaluate polygenic risk score-related workflows and tools," said Ken Wiley, Ph.D., program director in the Division of Genomic Medicine!

1. An increase in vaccination rates is the 'best way' out of COVID-19 and lockdowns - Sky News Australia
Jul 19, 2021 # health 19 secs
2. Mafia figure Frank Madafferi to be deported after two decades of trying by immigration - The Age
Jul 23, 2021 # politics 57 secs
3. Chris Hemsworth snaps selfie with fans at northern NSW KFC -
Jul 21, 2021 # entertainment 28 secs
4. Hamish Macdonald’s return to The Project forces Ten to dump Peter van Onselen from show - The Guardian Australia
Jul 21, 2021 # entertainment 1 min, 4 secs
5. Home and Away confirms kiss for Ziggy and Dean -
Jul 19, 2021 # entertainment 39 secs
6. Laser improves time resolution of CryoEM - Mirage News
Jul 20, 2021 # science 5 secs
7. NSW Chief Health Officer Kerry Chant says time to ‘rethink’ COVID vaccine rollout to include kids -
Jul 20, 2021 # health 18 secs
8. Unreleased Intel Core i9-12900K Alder Lake CPUs In China On Sale for 1000 USD -
Jul 19, 2021 # technology 29 secs
9. Angie Kent warns Jimmy Nicholson as she reveals the TRUTH about The Bachelor 'curse' - Daily Mail
Jul 23, 2021 # entertainment 59 secs
10. Perseid meteor shower 2021 is on now: How to watch the dazzling show - CNET
Jul 21, 2021 # science 38 secs
11. Recce Pharmaceuticals" R327 demonstrates positive efficacy against ‘flesh-eating" bacteria - Proactive Investors Australia
Jul 19, 2021 # health 1 min, 3 secs
12. Pro Evolution Soccer renamed to eFootball for 2021 launch - Polygon
Jul 21, 2021 # technology 33 secs
13. GRID Legends is a new story-driven racing game by Codemasters -, Edition: Australia
Jul 23, 2021 # technology 46 secs
14. Google Chrome 92 is making it easier to track permissions and fix safety issues - XDA Developers
Jul 20, 2021 # technology 45 secs
15. New Compound for Cystic Fibrosis Nonsense Mutations Detailed in Study - Cystic Fibrosis News Today
Jul 21, 2021 # health 1 min, 13 secs
16. South Australia’s ‘miraculous’ escape from ‘rogue’ removalists revealed -
Jul 17, 2021 # politics 51 secs


Get monthly updates and free resources.


© Copyright 2021 365NEWSX - All RIGHTS RESERVED