They said the modelling is believed to be the first of its kind to couple gastric biomechanics with pill movement and drug dissolution to quantify an active pharmaceutical ingredient passing through the pylorus into the duodenum.
"When the pill reaches the stomach, the motion of the stomach walls and the flow of contents inside determine the rate at which it dissolves.
"However, current experimental or clinical procedures for assessing the dissolution of oral drugs are limited in their ability to study this, which makes it a challenge to understand how the dissolution is affected in different stomach disorders, such as gastroparesis, which slows down the emptying of the stomach."?
Prof Mittal said: "This results in varying rates of pill dissolution and non-uniform emptying of the drug into the duodenum and, sometimes, gastric dumping in the case of modified-release dosage
"Our models can generate biorelevant data on drug dissolution that can provide useful and unique insights into the complex physiological processes behind the oral administration of pills."
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