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New study uncovers molecular mechanisms that coordinate skin cell senescence - ANI News

New study uncovers molecular mechanisms that coordinate skin cell senescence - ANI News

New study uncovers molecular mechanisms that coordinate skin cell senescence - ANI News
Jan 12, 2022 1 min, 31 secs

"We found that the protein CSDE1 coordinates a complex chain of events that enable senescence in skin cells, significantly slowing down their function without causing death," says Rosario Avolio, first author of the study and postdoctoral researcher at the CRG at the time of submission.

Researchers led by Fatima Gebauer at the Centre for Genomic Regulation (CRG) carried out the study by collecting keratinocytes from mice, the most abundant type of skin cell in the epidermis.

Keratinocytes can give rise to various types of skin cancer including basal and squamous cell carcinomas, two of the most frequently occurring forms of all human cancers.

The group experimentally introduced genes that drive the formation of cancer, which induced the cells into a state of senescence.

They found that when levels of CSDE1 were depleted, cells could not undergo senescence and became immortalised, a necessary step in the development of cancer.

Previous studies from the same group led by Dr Gebauer found that CSDE1 promotes the formation of metastases in melanoma, a less common but the most aggressive type of skin cancer.

It has an unpredictable dual nature depending on what type of cell and tissue it's found in," explains Dr Gebauer, acting co-coordinator of the Gene Regulation, Stem Cells and Cancer research programme at the CRG and senior author of the study.

CSDE1 is an RNA-binding protein, a type of protein that monitors RNA, often as soon as they're made with the potential to significantly change their function.

One possible theory that explains why CSDE1 behaves differently is that normal skin cells or tumours each have slightly different variants of the protein which affect the wider molecular machinery in different ways

The study is one of the few to examine the role of RNA-binding proteins in establishing cell senescence, which is an important new frontier in cancer research

Summarized by 365NEWSX ROBOTS

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