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A key component of the J&J vaccine could explain the risk of extremely rare blood clots - NBC News

A key component of the J&J vaccine could explain the risk of extremely rare blood clots - NBC News

Apr 14, 2021 1 min, 25 secs

A key ingredient in Johnson & Johnson’s Covid-19 vaccine could explain the possible link between the shots and the extremely rare blood clots reported in six patients in the U.S.

Rollout of Johnson & Johnson's vaccine was paused Tuesday, after six recipients developed a combination of severe blood clots in the brain called cerebral venous sinus thrombosis, or CVST, and low levels of platelets.

Meanwhile, some experts suspect the key technology used to make the Johnson & Johnson vaccine — as well as the AstraZeneca vaccine — may play a role in the blood clots.

The AstraZeneca vaccine, which is not yet authorized for any use in the U.S., has been linked to rare occurrences of blood clots in Europe and the United Kingdom.

These warnings came as a study published in the New England Journal of Medicine linked the AstraZeneca vaccine to reports of rare blood clots in 11 patients — nine of them women — in their 20s, 30s and 40s in Germany and Austria.

In the AstraZeneca vaccine, the modified virus comes from chimpanzees; in Johnson & Johnson's, the virus comes from humans.

No such clotting issues have been reported with the Covid-19 vaccines made by Pfizer-BioNTech or Moderna, health officials said.

Experts hypothesize that in very rare instances, the adenoviruses used in the Johnson & Johnson and the AstraZeneca Covid-19 vaccines might prompt the body to make antibodies similar to what's seen in heparin-induced thrombocytopenia.

But current evidence suggests the risk of blood clots is exceedingly rare.

"There is a larger risk of getting Covid-19 disease, and a presumably lesser risk of this blood clotting disorder.".

There are a handful of other vaccines that use the adenovirus technology, including Johnson & Johnson's Ebola vaccine

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