Age Accelerating “Zombie Cells” – A New Study Sheds Light on These Unique Cells - SciTechDaily

Age Accelerating “Zombie Cells” – A New Study Sheds Light on These Unique Cells - SciTechDaily

Age Accelerating “Zombie Cells” – A New Study Sheds Light on These Unique Cells - SciTechDaily
Aug 15, 2022 1 min, 26 secs

The study, which was recently published in the journal Nature Structural & Molecular Biology, demonstrates for the first time that oxidative damage to telomeres — the protecting tips of chromosomes that behave like plastic caps at the end of a shoelace — can cause cellular senescence.

“Although zombie cells don’t function properly, they’re not couch potatoes — they actively secrete chemicals that promote inflammation and damage neighboring cells.

Our study helps answer two big questions: How do senescent cells accumulate with age, and how do telomeres contribute to that?”.

For decades, scientists have known that telomere shortening causes senescence in lab-grown cells, but they could only assume that DNA damage at telomeres could convert cells into zombies.

When researchers used a novel tool to induce oxidative damage specifically at telomeres, they can become fragile (green arrows), sending cells into senescence.

Using human cells grown in a dish, the researchers found that damage at telomeres sent the cells into a zombie state after just four days — much faster than the weeks or months of repeated cell divisions that it takes to induce senescence by telomere shortening in the lab.

“We found a new mechanism for inducing senescent cells that is completely dependent on telomeres,” explained Opresko, who also co-leads the Genome Stability Program at UPMC Hillman.

Cells have repair pathways to patch up DNA lesions, but, according to Opresko, telomeres are “exquisitely sensitive” to oxidative damage.

The researchers found that damage at telomeres disrupted DNA replication and induced stress signaling pathways that led to senescence.

“By reducing the accumulation of zombie cells, which contribute to degenerative diseases, we might be able to promote ‘healthspan’ — the length of time that a person is healthy,” he added.

August 13, 2022

August 12, 2022

August 12, 2022

August 12, 2022

August 12, 2022

1 Here are Google’s Pixel 7 and 7 Pro cases, with some tweaks from last year [Gallery] - 9to5Google

Sep 20, 2022 # technology 48 secs

2 Hands-on with Apple Watch Ultra: First impressions and gallery - 9to5Mac

Sep 23, 2022 # politics 26 secs

3 Steve Hilton: Americans are sick and tired of extremism

Sep 26, 2022 # breaking 2 secs

4 America's Sexually Transmitted Disease Problem Is 'Out of Control' - Gizmodo

Sep 20, 2022 # politics 39 secs

5 Acid lake atop real-life 'Mount Doom' captured in striking new image from space station - Livescience.com

Sep 22, 2022 # science 1 min, 18 secs

6 Activists suing DeSantis over Martha's Vineyard flights received over $1.3M from George Soros network

Sep 21, 2022 # breaking 1 min, 36 secs

7 Meghan Markle complained about 'not getting paid' for 2018 royal tour, new book claims - New York Post

Sep 24, 2022 # entertainment 35 secs

8 A Cancer-Fighting Version of Herpes Shows Promise in Early Human Trial - Gizmodo

Sep 23, 2022 # health 58 secs

9 New diabetes study shows two drugs outperforming others - NewsNation Now

Sep 24, 2022 # health 8 secs

10 What's the 'longevity' diet, and will it really make you live longer?

Sep 21, 2022 # breaking 1 min, 2 secs

11 New York Yankees' Aaron Judge crushes 60th home run - ESPN

Sep 21, 2022 # politics 2 mins, 5 secs

12 Mortgage demand rises for the first time in six weeks, despite sharply higher interest rates - CNBC

Sep 21, 2022 # politics 27 secs

13 NASA Refines Its Strategy for Getting Humans to Mars - Gizmodo

Sep 22, 2022 # science 1 min, 5 secs

14 ‘Beverly Hills Cop’ Original Cast Members Returning for Netflix Sequel ‘Axel Foley’ - Variety

Sep 21, 2022 # entertainment 0 secs

15 CA mandatory kindergarten bill: Gov. Gavin Newsom rejects mandatory kindergarten law - KABC-TV

Sep 26, 2022 # politics 59 secs

16 GeForce GPUs are slowing down after installing the Windows 11 2022 Update - Ars Technica

Sep 24, 2022 # technology 33 secs

Get monthly updates and free resources.


© Copyright 2022 365NEWSX - All RIGHTS RESERVED