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Alzheimer's Disease Affects Most Known Biological Pathways in the Brain - Neuroscience News

Alzheimer's Disease Affects Most Known Biological Pathways in the Brain - Neuroscience News

Alzheimer's Disease Affects Most Known Biological Pathways in the Brain - Neuroscience News
Jun 25, 2022 1 min, 35 secs

Neuroscience research articles are provided.

Neuroscience can involve research from many branches of science including those involving neurology, brain science, neurobiology, psychology, computer science, artificial intelligence, statistics, prosthetics, neuroimaging, engineering, medicine, physics, mathematics, pharmacology, electrophysiology, biology, robotics and technology.

– These articles focus mainly on neurology research.

Genetics articles related to neuroscience research will be listed here.

Summary: Out of 341 known biological pathways, 91% are linked to Alzheimer’s disease.

Currently, the biological mechanisms underlying Alzheimer’s disease are poorly understood; as a result, there are few effective treatments and no cure for the disease.

In a recent study, a research team led by scientists at Beth Israel Deaconess Medical Center (BIDMC) conducted a systematic assessment of more than 200,000 scientific publications to understand the breadth and diversity of biological pathways—key molecular chain reactions that drive changes in cells—that contribute to Alzheimer’s disease by research over the last 30 years.

The team found that, while nearly all known pathways have been linked to the disease, the most frequently associated biological mechanisms—including those related to the immune system, metabolism and long-term depression—have not significantly changed in 30 years, despite major technological advances.

The scientists’ work, published in Frontiers in Aging Neuroscience, will advance research into the mechanisms of neurodegeneration.

Next, they looked at 341 known biological pathways and determined how many publications linked a given pathway to the disease.

The researchers found that 91 percent of pathways—all but seven—were linked to Alzheimer’s disease.

Nearly half of the pathways were linked to Alzheimer’s disease in more than 100 scientific papers.

“Clinical trials aiming to either delay the onset or slow the progression of Alzheimer’s disease have largely failed,” said study first author Sarah Morgan, a postdoctoral researcher at BIDMC during the extent of this research and now a lecturer at Queen Mary University of London.

Most Pathways Can Be Related to the Pathogenesis of Alzheimer’s Disease.


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