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Brain Support Cells Transfer Their Mitochondria to Fight Free Radicals - Neuroscience News

Brain Support Cells Transfer Their Mitochondria to Fight Free Radicals - Neuroscience News

Brain Support Cells Transfer Their Mitochondria to Fight Free Radicals - Neuroscience News
Aug 16, 2022 1 min, 10 secs

Neuroscience can involve research from many branches of science including those involving neurology, brain science, neurobiology, psychology, computer science, artificial intelligence, statistics, prosthetics, neuroimaging, engineering, medicine, physics, mathematics, pharmacology, electrophysiology, biology, robotics and technology.

Summary: Astrocytes enhance healing following a brain hemorrhage by transferring their mitochondria to damaged neurons.

After a brain hemorrhage, neural support cells called astrocytes enhance healing by transferring their mitochondria to damaged neurons.

The healthy mitochondria stimulate the production of a free radical-fighting enzyme, according to new research published in Journal of Neuroscience. .

Astrocytes transfer their mitochondria to damaged neurons after a hemorrhage.

These healthy mitochondria contain a “healing” peptide called humanin and an enzyme called manganese superoxide dismutase (Mn-SOD) that help neutralize free radicals.

injected mice with healthy mitochondria after a hemorrhage.

“Transplantation of astrocytic mitochondria modulates neuronal antioxidant defense and neuroplasticity and promotes functional recovery after intracerebral hemorrhage” by Tashiro et al.

Transplantation of astrocytic mitochondria modulates neuronal antioxidant defense and neuroplasticity and promotes functional recovery after intracerebral hemorrhage.

However, a relevance of astrocytic Mt transfer into neurons in protecting brain after ICH is unclear

The damaging effect of ICH was reversed by intravenous transplantation of astrocytic Mt that upon entering the brain (and neurons), restored Mn-SOD levels and reduced neurological deficits in male mice subjected to ICH

This study demonstrates that adoptive astrocytic Mt transfer enhances neuronal Mn-SOD-mediated anti-oxidative defense and neuroplasticity in the brain, which potentiate functional recovery following ICH


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