Breast cancer risk: What is the PALB2 gene mutation? Expert weighs in - Fox News
Oct 13, 2021 1 min, 0 secs

BRCA gene mutations are well known indicators of a person’s risk for breast cancer, however the PALB2 mutation is the third most prevalent breast cancer gene experts say people should be aware of in determining risk for developing the disease.

Researchers have linked the PALB2 gene mutation to diseases like breast, ovarian and pancreatic cancers, medical experts told Fox News.

Breast Cancer 1 (BRCA1) and Breast Cancer 2 (BRCA2) gene mutations are the top two mutations highly associated with inherited cancers such as breast and ovarian cancer, as well as pancreatic, prostate and melanoma cancers.

Elisa Port, chief of breast surgery at Mount Sinai Health System, told Fox News that the BRCA and PALB2 gene mutations do share similar risks, yet differ.

According to Port, who also serves as the director of the Dubin Breast Center at Tisch Cancer Institute at Mount Sinai, the risk of ovarian cancer with BRCA can be up to 20% or 40% depending on the BRCA gene.

A normal healthy gene decreases one's risk of developing breast cancer, NBCF explains on its webpage.

Testing for genetic mutations is important when discussing one’s risk and prevention of certain diseases like cancer, Port said, noting: "It’s not just BRCA and PALB2

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