"Tha God's Honest Truth with Lenard 'Charlamagne' McKelvey" will debut on Comedy Central on Friday nights starting Sept.
The show brings Colbert back to Comedy Central for the first since "The Colbert Report," a satirical take on personality driven political shows, ended its 11-season run in 2014.
Charlamagne and Colbert, both from South Carolina, said they bonded over their shared background.
"My South Carolina brethren Stephen Colbert is the ultimate co-sign in the late night space and he wouldn't co-sign no bull----!" Charlamagne said.
"For too long, the town of Moncks Corner, South Carolina, has been underrepresented in late night," Colbert said, referring to where Charlamagne grew up.