Experimental Cancer Drug Shows Early Promise as Alzheimer's Treatment in Mouse Study - ScienceAlert
Dec 03, 2021 47 secs

By blocking off the effects of the mutation in tests on mice, the team was able to reverse some of the inflammatory effects and synaptic toxicity (neuron damage) that's usually seen as Alzheimer's disease progresses in the brain.

There are numerous genetic variations that are associated with an increased risk of Alzheimer's disease, and many of them are highly expressed in microglia, suggesting that alterations to these cells are somehow linked to the progress of the condition.

What makes research into the disease especially difficult is that we're still not sure exactly what causes it or how it starts – but scientists are able to study the effects of Alzheimer's as it progresses, and can work backwards from there to look for clues.

"We identified a small molecule compound that has been tested in patients with cancer, readily enters the brain, potently modulates the brain's immune responses, and protects against synaptic loss in animal models of Alzheimer's disease," says Gan.


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