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Experimental Vaccine Would Be the First to Fight Off Fungi - Gizmodo

Experimental Vaccine Would Be the First to Fight Off Fungi - Gizmodo

Experimental Vaccine Would Be the First to Fight Off Fungi - Gizmodo
Feb 06, 2023 54 secs

Among other reasons, our bodies are too hot for most fungi to survive comfortably in, and our immune system generally does a good job of keeping potential infections from running rampant.

As more people live with conditions that at least temporarily weaken their immune system, such as those undergoing cancer treatment, fungal infections are expected to rise.

Their experimental vaccine is meant to boost protection in immunocompromised people against three of the most common groups of fungi known to cause fatal infections in humans: Pneumocystis, Aspergillus, and Candida.

None of the vaccinated macaques exposed to Pneumocystis fungi developed the severe infection it can cause, for instance, compared to more than half that did in the unvaccinated group.

“Because it targets three different pathogens, the vaccine has the potential to be groundbreaking regarding invasive fungal infections,” said lead author Karen Norris, a professor in the College of Veterinary Medicine at UGA, in a recent statement from the university.

The team is preparing to start a Phase I trial of their vaccine, which will assess its safety and immune response in healthy human volunteers.

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