Born in 1931, Bartholomew attended Nelson Street Boys’ RC School and St Mary’s College before studying medicine at University College Dublin, Ireland and graduating in 1960.
According to both a St Mary's College Past Students' Union post and the Niherst website, he received a specialised degree in gastroenterology in 1964 and a doctorate in medicine from the National University of Ireland in 1965.
In 1967 he was recruited from the Royal Victoria Hospital of Mc Gill University to inaugurate the first medical school of UWI, and in 1977 became UWI’s first Trinidadian professor of medicine
He was an international bioethics adviser, an external examiner for the University of Ibadan, Nigeria, and visiting clinical professor at the Liver Unit, University of Miami and Royal Victoria Hospital, McGill University