Metabolism Linked to Brain Health - Neuroscience News

Metabolism Linked to Brain Health - Neuroscience News

Metabolism Linked to Brain Health - Neuroscience News
Sep 29, 2022 1 min, 55 secs

Summary: Researchers have identified a link between metabolism and dementia-related brain measures.

Obesity related to inflammation, kidney stress, or liver stress had the biggest impact on adverse brain health.

Now, a world-first study from the University of South Australia’s Australian Center for Precision Health has found a link between metabolism and dementia-related brain measures, providing valuable insights about the disease.

The study measured associations of six diverse metabolic profiles and 39 cardiometabolic markers with MRI brain scan measures of brain volume, brain lesions, and iron accumulation, to identify early risk factors for dementia.

People with metabolic profiles linked to obesity were more likely to have adverse MRI profiles showing lower hippocampal and gray matter volumes, greater burden of brain lesions, and higher accumulation of iron.

Amanda Lumsden, says the research adds a new layer of understanding to brain health.

Metabolic profile‐based subgroups can identify differences in brain volumes and brain iron deposition

To evaluate associations of metabolic profiles and biomarkers with brain atrophy, lesions, and iron deposition to understand the early risk factors associated with dementia

Using data from 26 239 UK Biobank participants free from dementia and stroke, we assessed the associations of metabolic subgroups, derived using an artificial neural network approach (self-organizing map), and 39 individual biomarkers with brain MRI measures: total brain volume (TBV), grey matter volume (GMV), white matter volume (WMV), hippocampal volume (HV), white matter hyperintensity (WMH) volume, and caudate iron deposition

In metabolic subgroup analyses, participants characterized by high triglycerides and liver enzymes showed the most adverse brain outcomes compared to the healthy reference subgroup with high-density lipoprotein cholesterol and low body mass index (BMI) including associations with GMV (βstandardized −0.20, 95% confidence interval [CI] −0.24 to −0.16), HV (βstandardized −0.09, 95% CI −0.13 to −0.04), WMH volume (βstandardized 0.22, 95% CI 0.18 to 0.26), and caudate iron deposition (βstandardized 0.30, 95% CI 0.25 to 0.34), with similar adverse associations for the subgroup with high BMI, C-reactive protein and cystatin C, and the subgroup with high blood pressure (BP) and apolipoprotein B

Among the biomarkers, striking associations were seen between basal metabolic rate (BMR) and caudate iron deposition (βstandardized 0.23, 95% CI 0.22 to 0.24 per 1 SD increase), GMV (βstandardized −0.15, 95% CI −0.16 to −0.14) and HV (βstandardized −0.11, 95% CI −0.12 to −0.10), and between BP and WMH volume (βstandardized 0.13, 95% CI 0.12 to 0.14 for diastolic BP)

Associations of BMR, BP and other individual biomarkers may provide insights into actionable mechanisms driving these brain associations

1 Pete Davidson and Emily Ratajkowski Attend New York Knicks Game Together - E! NEWS

Nov 28, 2022 # entertainment 35 secs

2 Trouble Sleeping? You Could Be at Risk of Type 2 Diabetes - Neuroscience News

Dec 02, 2022 # health 1 min, 17 secs

3 PlayStation Plus Games for December 2022 Announced - IGN

Nov 30, 2022 # technology 27 secs

4 Zens’ new Apple MagSafe multicharger powers up to four devices - The Verge

Nov 30, 2022 # technology 35 secs

5 China links COVID outbreak to man’s jog through a park; Scientists skeptical - Ars Technica

Nov 29, 2022 # health 1 min, 25 secs

6 Dwayne Johnson Reveals Warner Bros. Didn’t Want Henry Cavill To Return As Superman - Deadline

Nov 27, 2022 # entertainment 42 secs

7 A mash made in heaven! POTATOES can help you lose weight, scientists say - Daily Mail

Nov 28, 2022 # health 1 min, 22 secs

8 Getting pregnant soon after abortion or miscarriage might have lower risks than previously suspected: study - Fox News

Nov 28, 2022 # health 1 min, 44 secs

9 Warzone 2.0: The DMZ AI Difficulty Is Too Damn High - Kotaku

Dec 02, 2022 # technology 58 secs

10 T.J. Holmes Had Years-Long Affair With a 'Good Morning America' Producer Before Amy Robach Romance - Entertainment Tonight

Dec 03, 2022 # politics 1 min, 0 secs

11 In rancid Hollywood tradition, Kevin Spacey gets a new film role - The A.V. Club

Nov 29, 2022 # entertainment 28 secs

12 Android 13 for Samsung's beastly Galaxy A52s 5G goes international - SamMobile - Samsung news

Nov 30, 2022 # technology 1 min, 7 secs

13 iOS 16.1.2 Update: Every New iPhone Feature We Know and How to Get It - CNET

Dec 02, 2022 # technology 41 secs

14 WWE Raw Results (11/28) - The Miz Vs. Dexter Lumis In A High Stakes Match, We Hear From Becky Lynch, WarGames Fallout & More - Wrestling Inc.

Nov 29, 2022 # entertainment 3 mins, 34 secs

15 Palm e-Tattoo Can Tell When You’re Stressed Out - Neuroscience News

Dec 04, 2022 # health 1 min, 23 secs

16 All of Kate Middleton's best outfits from her Boston tour with Prince William - Page Six

Dec 02, 2022 # entertainment 1 min, 32 secs

Get monthly updates and free resources.


© Copyright 2022 365NEWSX - All RIGHTS RESERVED