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Molecular Mechanisms Behind Learning and Memory Identified - Neuroscience News

Molecular Mechanisms Behind Learning and Memory Identified - Neuroscience News

Molecular Mechanisms Behind Learning and Memory Identified - Neuroscience News
Jun 27, 2022 2 mins, 0 secs

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Summary: Findings reveal the molecular mechanism for acetylcholine in learning and memory.

Now, researchers have identified the intracellular signal cascade through which ACh regulates aversive learning, a major preliminary test for AD drugs.

Researchers also found that donepezil activates this signal cascade to regulate aversive learning.

We then examined the involvement of the identified ACh-M1R-PKC-Rac-β-PIX-PAK cascade in aversive learning and aversion memory by using passive avoidance tests in mice,” says Dr.

Finally, the researchers also found that donepezil activates the cascade to enhance aversive learning.

The team’s findings directly imply that the signal cascade, M1R-PKC-β-PIX-PAK, is involved in recognition memory and associative learning.

“We are only seeing the tip of the iceberg and believe future research could yield novel mechanisms of signal transduction in other brain areas,” says Dr.

“Phosphoproteomic of the acetylcholine pathway enables discovery of the PKC-β-PIX-Rac1-PAK cascade as a stimulatory signal for aversive learning” by Yukie Yamahashi et al.

Phosphoproteomic of the acetylcholine pathway enables discovery of the PKC-β-PIX-Rac1-PAK cascade as a stimulatory signal for aversive learning.

The cholinesterase inhibitor donepezil increases brain acetylcholine levels and improves Alzheimer’s disease (AD)-associated learning disabilities.

Acetylcholine activates striatal/nucleus accumbens dopamine receptor D2-expressing medium spiny neurons (D2R-MSNs), which regulate aversive learning through muscarinic receptor M1 (M1R).

These findings demonstrate that acetylcholine stimulates M1R-PKC-β-PIX-Rac1-PAK signaling in D2R-MSNs for aversive learning and imply the cascade’s therapeutic potential for AD as aversive learning is used to preliminarily screen AD drugs

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