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New Drug a Hopeful Advance for Incurable Neurodegenerative Myelin Diseases - Neuroscience News

New Drug a Hopeful Advance for Incurable Neurodegenerative Myelin Diseases - Neuroscience News

New Drug a Hopeful Advance for Incurable Neurodegenerative Myelin Diseases - Neuroscience News
Dec 02, 2022 1 min, 12 secs

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Published in the journal Molecular Brain, the new research shows that the drug Riluzole, approved by the U.S.

“Riluzole partially restores RNA polymerase III complex assembly in cells expressing the leukodystrophy-causative variant POLR3B R103H” by Maxime Pinard et al.

Riluzole partially restores RNA polymerase III complex assembly in cells expressing the leukodystrophy-causative variant POLR3B R103H

This assay was used to dissect the stages of Pol III assembly, to start defining the function of the PAQosome in this process, to dissect the assembly defects driven by the leukodystrophy-causative R103H substitution in POLR3B, and to discover that riluzole, an FDA-approved drug for alleviation of ALS symptoms, partly corrects these assembly defects

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