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Potential Therapeutic Target for Schizophrenia Identified - Neuroscience News

Potential Therapeutic Target for Schizophrenia Identified - Neuroscience News

Potential Therapeutic Target for Schizophrenia Identified - Neuroscience News
Feb 08, 2023 38 secs

Schizophrenia is characterized by auditory and visual hallucinations, delusions, and trouble with forming and sorting thoughts, which severely impacts productivity and overall quality of life.

The disease, which affects roughly one percent of the general population, has strong genetic associations, however the exact genes involved are unknown.

Excitatory Dysfunction Drives Network and Calcium Handling Deficits in 16p11.2 Duplication Schizophrenia Induced Pluripotent Stem Cell–Derived Neurons

iENs from 16p11.2 duplication-carrying patients with SCZ displayed overlapping deficits in network synchrony, dendrite outgrowth, and calcium handling.

Transcriptomic analysis of both iEN cohorts revealed molecular markers of disease related to the glutamatergic synapse, neuroarchitecture, and calcium regulation.

Transcriptomics and cellular phenotyping reveal overlap between isogenic and patient-derived iENs, suggesting a central role of glutamatergic, morphological, and calcium dysregulation in 16p11.2 duplication-mediated pathogenesis.

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