Rare gene variant, which appears more in Amish communities, may hold key to preventing heart disease - Daily Mail
Dec 05, 2021 45 secs

A rare gene variant that typically appears in Amish communities may hold the key to preventing heart disease, according to researchers from the University of Maryland School of Medicine.

The study found that those that have this particular gene, known as B4GALT1, appear to have lower levels of heart-damaging cholesterol, as well as a blood-clotting protein called fibrinogen. .

Amazingly, 12 percent of the Pennsylvania Amish community in Lancaster County, pictured, carry the gene variant

Those that have this particular gene, known as B4GALT1, pictured, appear to have lower levels of heart-damaging cholesterol, as well as a blood-clotting protein called fibrinogen

The study ultimately found a connection between having the B4GALT1 gene variant and nearly 14 mg/dL lower LDL cholesterol with 30 mg/dL lower fibrinogen

'The mouse model, encoding for this gene mutation, also showed decreased levels of LDL cholesterol and fibrinogen, confirming the effect of this variant,' reports study leader Giusy Della Gatta. 


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