Dec 03, 2021 2 mins, 51 secs
Re­searchers may be near­ing an an­swer for the mys­te­ri­ous and life-threat­en­ing blood clots that ap­peared on very rare oc­ca­sions in peo­ple who re­ceived the J&J or As­traZeneca Covid-19 vac­cine.

They pro­posed the events were sim­i­lar to blood clots that can oc­cur in a small sub­set of pa­tients who re­ceive he­parin, one of the most com­mon­ly used blood thin­ners.

In those pa­tients, he­parin binds to a pro­tein float­ing in the blood called platelet fac­tor 4, or PF4, to form a com­plex.

Peo­ple who took the J&J or As­traZeneca vac­cine and then suf­fered life-threat­en­ing blood clots al­so test pos­i­tive for an­ti-PF4 an­ti­bod­ies, just as pa­tients with he­parin-in­duced clots do.

Af­ter re­ports of the blood clots emerged, Alexan­der Bak­er, a re­searcher at Mayo who fo­cus­es on en­gi­neer­ing virus­es for ther­a­pies and vac­cines, de­cid­ed to take a clos­er look at the As­traZeneca vac­cine’s struc­ture.

“It seemed rea­son­able that there was some kind of in­ter­ac­tion be­tween the vac­cine and [PF4],” Bak­er told End­points News.

If re­searchers can pin down ex­act­ly how they bind to PF4, they might be able to swap out amino acids to pro­duce a virus that’s still func­tion­al for vac­cines but can’t bind to PF4 or cause blood clots.

And the risk of blood clots from Covid-19 — along with all the oth­er risks the dis­ease brings — far out­strips the risk from the shot.

“I think it is super worrisome,” Dartmouth professor and Adagio co-founder and CEO Tillman Gerngross told Endpoints News this weekend.

Unlock this story instantly and join 124,500+ biopharma pros reading Endpoints daily — and it's free.

Unlock this story instantly and join 124,500+ biopharma pros reading Endpoints daily — and it's free.

Unlock this story instantly and join 124,500+ biopharma pros reading Endpoints daily — and it's free.

Three top biopharma companies are seeking more details from the FDA on how the agency conducts its benefit-risk assessments for new drugs and biologics.

Unlock this story instantly and join 124,500+ biopharma pros reading Endpoints daily — and it's free.

Unlock this story instantly and join 124,500+ biopharma pros reading Endpoints daily — and it's free

ENDPOINTS NEWSby John Carroll & team — all the news at 11:30am ET

EARLY EDITIONby Arsalan Arif — news and links at 7:15am ET

ENDPOINTS MANUFACTURINGWeekly biopharma manufacturing report, Thursdays at 2pm ET

ENDPOINTS FDA+Regulatory news and analysis for drug developers, Wednesday 2pm ET


1. American Girl introduces Chinese-American doll as its "Girl of the Year"
Jan 10, 2022 # breaking 2 secs
2. Google Exec Pushing RCS Adoption Says He's 'Not Asking Apple to Make iMessage Available on Android' - MacRumors
Jan 11, 2022 # technology 32 secs
3. PCI Express Bandwidth Test: PCIe 4.0 vs. PCIe 3.0 Gaming Performance & Limited VRAM Memory Buffers - TechSpot
Jan 17, 2022 # politics 5 mins, 36 secs
4. Absurdle: the machiavellian version of Wordle - The Guardian
Jan 13, 2022 # politics 1 min, 16 secs
5. Bachelorette Alum Clint Arlis Dead at 34 - E! NEWS
Jan 14, 2022 # politics 34 secs
6. Bidenflation Crushed Workers in 2021: Three Worst Annual Real Wage Contractions on Record
Jan 12, 2022 # breaking 14 secs
7. U.S. consumer prices soared 7 percent in past year, most since 1982
Jan 12, 2022 # breaking 58 secs
8. 'Sister Wives': Why Christine Brown Leaves Marriage to Kody and Packs Up His Things - Showbiz Cheat Sheet
Jan 17, 2022 # entertainment 36 secs
9. Sources: Simon Cowell, Lauren Silverman in ‘crisis’ before engagement - Page Six
Jan 12, 2022 # entertainment 2 mins, 6 secs
10. Parents react to Disney's 'Encanto,' call it triggering and healing - KSL.com
Jan 16, 2022 # entertainment 1 min, 51 secs
11. Sony Denies Bloomberg's Report that PS4 Production is Continuing in 2022 to Make Up for PS5 Shortage - Anime News Network
Jan 14, 2022 # technology 27 secs
12. China has built an 'artificial moon' research facility with a lunar-like low gravity environment - Daily Mail
Jan 12, 2022 # science 1 min, 26 secs
13. China's economy expanded 8.1% in 2021, but growth is slowing - CNN
Jan 17, 2022 # politics 1 min, 39 secs
14. Tucker: Biden made it clear Americans cannot peacefully protest
Jan 15, 2022 # breaking 2 secs
15. Unvaccinated Women With Covid Are More Likely to Lose Fetuses and Infants, Data Shows - The New York Times
Jan 13, 2022 # health 54 secs
16. California governor denies parole to Robert F. Kennedy assassin Sirhan Sirhan
Jan 13, 2022 # breaking 1 min, 24 secs

SUBSCRIBE

Get monthly updates and free resources.

CONNECT WITH US

© Copyright 2022 365NEWSX - All RIGHTS RESERVED