They proposed the events were similar to blood clots that can occur in a small subset of patients who receive heparin, one of the most commonly used blood thinners.
In those patients, heparin binds to a protein floating in the blood called platelet factor 4, or PF4, to form a complex.People who took the J&J or AstraZeneca vaccine and then suffered life-threatening blood clots also test positive for anti-PF4 antibodies, just as patients with heparin-induced clots do.
After reports of the blood clots emerged, Alexander Baker, a researcher at Mayo who focuses on engineering viruses for therapies and vaccines, decided to take a closer look at the AstraZeneca vaccine’s structure.“It seemed reasonable that there was some kind of interaction between the vaccine and [PF4],” Baker told Endpoints News.If researchers can pin down exactly how they bind to PF4, they might be able to swap out amino acids to produce a virus that’s still functional for vaccines but can’t bind to PF4 or cause blood clots.
And the risk of blood clots from Covid-19 — along with all the other risks the disease brings — far outstrips the risk from the shot.
“I think it is super worrisome,” Dartmouth professor and Adagio co-founder and CEO Tillman Gerngross told Endpoints News this weekend. Unlock this story instantly and join 124,500+ biopharma pros reading Endpoints daily — and it's free. Unlock this story instantly and join 124,500+ biopharma pros reading Endpoints daily — and it's free. Unlock this story instantly and join 124,500+ biopharma pros reading Endpoints daily — and it's free.Three top biopharma companies are seeking more details from the FDA on how the agency conducts its benefit-risk assessments for new drugs and biologics. Unlock this story instantly and join 124,500+ biopharma pros reading Endpoints daily — and it's free. Unlock this story instantly and join 124,500+ biopharma pros reading Endpoints daily — and it's freeENDPOINTS NEWSby John Carroll & team — all the news at 11:30am ET
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