This did not impact the development of blood cells inside the bone marrow, but it did lead to a significant reduction of CLP, which led to fewer lymphocytes ready to fight infections.
They placed mice in cages with running wheels and discovered that running led to a higher number of Oln+ and CLP cells in the bone marrow.
The authors also found that the numbers of Oln+ and CLP cells were lower in the bone marrow of 18-month-old mice than 2-month-old animals.All animals were active, which indicates that other factors had reduced the expressions of those cells, which could lead to immune system issues.