In a statement, Apple described the partnership as "the first of its kind."
"Singapore has one of the world's leading healthcare systems, and we are thrilled to be partnering with them," said chief operating officer Jeff Williams.
The announcement is timely for Apple, which just announced two new smartwatch models this week at its big September event.
One of the watches comes with upgraded health features, including an app that lets users keep an eye on their blood oxygen levels.
The announcement also came days after the company opened its third store in Singapore — an eye-catching glass dome that was inspired by the Pantheon in Rome.
The space is designed to look like a "floating sphere," according to Apple.