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‘Special’ Muscle Can Promote Glucose and Fat Burning to Fuel Metabolism for Hours While Sitting - Neuroscience News

‘Special’ Muscle Can Promote Glucose and Fat Burning to Fuel Metabolism for Hours While Sitting - Neuroscience News

‘Special’ Muscle Can Promote Glucose and Fat Burning to Fuel Metabolism for Hours While Sitting - Neuroscience News
Sep 22, 2022 2 mins, 48 secs

Summary: The pioneering “soleus pushup” effectively elevates muscle metabolism for hours, even when sitting.

From the same mind whose research propelled the notion that “sitting too much is not the same as exercising too little,” comes a groundbreaking discovery set to turn a sedentary lifestyle on its ear: The soleus muscle in the calf, though only 1% of your body weight, can do big things to improve the metabolic health in the rest of your body if activated correctly.

And Marc Hamilton, professor of Health and Human Performance at the University of Houston, has discovered such an approach for optimal activation – he’s pioneering the “soleus pushup” (SPU) which effectively elevates muscle metabolism for hours, even while sitting.

The soleus, one of 600 muscles in the human body, is a posterior leg muscle that runs from just below the knee to the heel. .

Published in the journal iScience, Hamilton’s research suggests the soleus pushup’s ability to sustain an elevated oxidative metabolism to improve the regulation of blood glucose is more effective than any popular methods currently touted as a solution including exercise, weight loss and intermittent fasting.

Oxidative metabolism is the process by which oxygen is used to burn metabolites like blood glucose or fats, but it depends, in part, on the immediate energy needs of the muscle when it’s working. .

“When activated correctly, the soleus muscle can raise local oxidative metabolism to high levels for hours, not just minutes, and does so by using a different fuel mixture.”  .

Instead of breaking down glycogen, the soleus can use other types of fuels such as blood glucose and fats?

The new approach of keeping the soleus muscle metabolism humming is also effective at doubling the normal rate of fat metabolism in the fasting period between meals, reducing the levels of fat in the blood (VLDL triglyceride). .

Building on years of research, Hamilton and his colleagues developed the soleus pushup, which activates the soleus muscle differently than when standing or walking.

The SPU targets the soleus to increase oxygen consumption – more than what’s possible with these other types of soleus activities, while also being resistant to fatigue. .

“The soleus pushup looks simple from the outside, but sometimes what we see with our naked eye isn’t the whole story.

Hamilton calls it the “most important study” ever completed at his Metabolic Innovations lab at UH and said the discovery could be a solution to a variety of health problems caused by spending hours each day living with muscle metabolism that is too low, caused by inactivity

“All of the 600 muscles combined normally contribute only about 15% of the whole-body oxidative metabolism in the three hours after ingesting carbohydrate

“A potent physiological method to magnify and sustain soleus oxidative metabolism improves glucose and lipid regulation” by Marc Hamilton et al

A potent physiological method to magnify and sustain soleus oxidative metabolism improves glucose and lipid regulation

Slow oxidative muscle, most notably the soleus, is inherently well equipped with the molecular machinery for regulating blood-borne substrates

We found the human soleus muscle could raise local oxidative metabolism to high levels for hours without fatigue, during a type of soleus-dominant activity while sitting, even in unfit volunteers

Targeting a small oxidative muscle mass (∼1% body mass) with local contractile activity is a potent method for improving systemic metabolic regulation while prolonging the benefits of oxidative metabolism


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