One adviser said Trump needs a "leadership moment" at the debate as Biden is now seen as the front-runner heading into the final stretch of this campaign.
Trump won those voters by 30 points in 2016, but he currently holds only a 19-point margin within that demographic, according to an analysis by CNN's Harry Enten.
Biden, who was born in Scranton, Pennsylvania, has proven to be a more formidable adversary than Clinton when it comes to those voters -- one of the reasons why he is faring better in Midwestern states than the 2016 Democratic nominee.
To bolster his standing, Trump's advisers hope he will be laser-focused on the economy, an area where he has traditionally held a clear advantage over Biden.