The British champ battered Wilder until the seventh round, when Wilder's corner threw in the towel on a one-sided victory and Fury claimed Wilder's WBC belt.
In the final minute of the third, Fury stunned Wilder with a shot and then escaped a clinch to land a two-punch combination that put Wilder down to his knees.
Fury battered Wilder again with the crowd on its feet, but Wilder made it to the bell.
Fury appeared to be in control until late in the fourth, when Wilder landed a powerful right hand squarely to the top of Fury's head.Fury hurt Wilder in the seventh with a series of punches that sent Wilder sprawling back against the ropes.
Another damaging right hand from Fury swept Wilder's legs out from under him in the 10th, but Wilder finished the round, even hurting Fury late.Wilder reached for the ropes on his way down, but landed facedown with his eyes glassy.