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Vitamin D Supplementation Seems to Alleviate Depressive Symptoms in Adults - Neuroscience News

Vitamin D Supplementation Seems to Alleviate Depressive Symptoms in Adults - Neuroscience News

Vitamin D Supplementation Seems to Alleviate Depressive Symptoms in Adults - Neuroscience News
Aug 12, 2022 1 min, 30 secs

Summary: The findings of an extensive meta-analysis study reveal vitamin D supplementation may help to alleviate symptoms of depression.

An extensive meta-analysis suggests that vitamin D supplementation may alleviate depressive symptoms in adults with depression.

The therapeutic efficacy of current antidepressants is often insufficient, which is why further ways to alleviate the symptoms of depression have been sought, for example, from nutritional research.

However, previous meta-analyses on the effects of vitamin D supplementation on depression have been inconclusive.

The new meta-analysis on the association of vitamin D supplementation with depression is the largest one published so far, including results from 41 studies from around the world.

These studies have investigated the efficacy of vitamin D in alleviating depressive symptoms in adults by randomized placebo-controlled trials in different populations.

The results of the meta-analysis show that vitamin D supplementation is more effective than a placebo in alleviating depressive symptoms in people with depression.

“These findings will encourage new, high-level clinical trials in patients with depression in order to shed more light on the possible role of vitamin D supplementation in the treatment of depression,” Mikola concludes.

“The effect of vitamin D supplementation on depressive symptoms in adults: A systematic review and meta‐analysis of randomized controlled trials” by Tuomas Mikola et al.

The effect of vitamin D supplementation on depressive symptoms in adults: A systematic review and meta‐analysis of randomized controlled trials.

Meta‐analyses investigating the effect of vitamin D on depression have been inconsistent.

This meta-analysis investigated the efficacy of vitamin D in reducing depressive symptoms among adults in randomized placebo-controlled trials (RCT).

Results for main outcome (n = 53,235) revealed a positive effect of vitamin D on depressive symptoms (Hedges’ g = −0.317, 95% CI [−0.405, −0.230], p < 0.001, I2 = 88.16%; GRADE: very low certainty)

Notwithstanding high heterogeneity, vitamin D supplementation ≥ 2,000 IU/day appears to reduce depressive symptoms


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