Can't lose weight by dieting alone? Researchers have bad news for you - New York Post

Researchers at the University of Ottowa have identified a separate group of obese people who are especially resistant to losing weight through dietary changes alone, according to a report published on Wednesday in The Lancet’s eBioMedicine journal.

“If you look at a large group of people who are overweight and trying to lose weight, they don’t respond to exercise very much.

Those considered to have “diet-resistant” obesity fall in the bottom 20% for the rate of weight loss while following a low-calorie diet.

Fat metabolism in the skeletal muscle is regulated by the mitochondria, and those with “diet-resistant” obesity show lower mitochondrial activity in their bones than those with “diet-sensitive” obesity, according to the researchers.

“For those individuals who have obesity and who’ve had enormous difficulty losing weight, the message for them is: You are in a group of individuals for whom exercise is particularly important,” McPhereson added.

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