Diet High in Guar Gum Fiber Limits Inflammation and Multiple Sclerosis Symptoms - Neuroscience News

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Summary: Diets high in guar gum, a dietary fiber and common food additive extracted from guar beans, limit inflammation and delay the onset of multiple sclerosis in mouse models.

Diets high in guar gum, a common food additive and dietary fibre, limited inflammation and delayed the onset of multiple sclerosis (MS) symptoms in mice, according to new research by members of the University of British Columbia (UBC) Microbiology and Immunology department.

Our study gives us a clearer window into the potential of several sources of fibre in maintaining immune health.”.

Osborne and colleagues exposed groups of mice to a variety of diets—a control five percent cellulose fibre diet, a diet entirely lacking in dietary fibre, or diets enriched (30%) with fibre in either resistant starch, inulin, pectin, or guar gum.

Guar gum—guaran—is extracted from guar beans, and is often used as an additive to thicken and stabilize food and animal feed, and in industrial applications.

“Guar beans aren’t that common in western diets, and the gum isn’t used at these high levels as an additive in the west,” says Naomi Fettig, first author on the study and a PhD student with the Department of Microbiology and Immunology at UBC.

“Experts have consistently been saying fibre is good for you—and a variety of fibre sources is important to immune health—but there hasn’t been very much critical work into identifying how the body responds to different fibre types.

“Incorporating guar beans might be challenging to achieve at the doses we gave to mice,” says Dr.

Osborne and her lab now want to explore the potential benefits in humans—including developing a more detailed understanding of the molecular picture, which might help design therapeutics that offer the benefits of such high guar gum diets in a more practical form. .

“Inhibition of Th1 activation and differentiation by dietary guar gum ameliorates experimental autoimmune encephalomyelitis” by Lisa Osborne et al.

Inhibition of Th1 activation and differentiation by dietary guar gum ameliorates experimental autoimmune encephalomyelitis.

In a direct comparison of four different high-fiber diets, we demonstrate a potent ability of guar gum to delay disease and neuroinflammation in experimental autoimmune encephalomyelitis, a T cell-mediated mouse model of multiple sclerosis