Prisco's NFL Week 6 picks: Chargers upset Ravens in shootout, Browns hand Cardinals first loss, Cowboys cruise - CBS Sports

Just once can I have a winning week picking all the games straight up, all the games against the spread and also my Best Bets on the Pick Six Podcast.

The Eagles are coming off an impressive road victory over Carolina, and you know they will be juiced here playing the champs.

Tom Brady lit up the Dolphins last week, but on a short week this is a real challenge.

The Dolphins defense was shredded by Tom Brady last week, but Trevor Lawrence is far from Brady and doesn't have the same types of weapons.

Pick: Dolphins 24, Jaguars 20.

The Colts are playing on a short week after losing to the Ravens in gut-wrenching fashion Monday night.

Cincinnati is coming off one of its own tough losses to Green Bay last week.

Aaron Rodgers will get the best of that defense.

Even playing consecutive road games, the Packers take it.

The Vikings will be on the road for the first time since Week 2.

The matchup of the Minnesota offense against the Carolina defense will decide this, and I think the Vikings will get the best of it.

This is one of the best games of the week as the undefeated Cardinals play at the Browns, who are coming off a tough loss to the Chargers.

Both these teams have lost two straight games after opening 3-0, and the Raiders will now be playing without Jon Gruden as coach.

The Broncos showed well in coming back last week against the Steelers, but they fell short

Davis Mills picked apart the New England defense last week, and now Dak Prescott will do the same

It's a tough way to start on the road against the Steelers defense

The Steelers seemed to find some life on offense against Denver, while the Seahawks defense is awful

Pick: Steelers 27, Seahawks 13

This is one of those be-careful games for the Bills, who could be caught in a letdown after beating the Chiefs on the road Sunday night

Pick: Bills 27, Titans 24