Repeated Stress Accelerates Aging of the Eye - Neuroscience News

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Summary: Stress such as intraocular pressure elevation in the eye causes the retinal tissue to undergo transcriptional and epigenetic changes similar to natural aging.

The team shows how stress, such as intraocular pressure (IOP) elevation in the eye, causes retinal tissue to undergo epigenetic and transcriptional changes similar to natural aging.

And, how in young retinal tissue, repetitive stress induces features of accelerated aging including the accelerated epigenetic age.

“The epigenetic changes we observed suggest that changes on the chromatin level are acquired in an accumulative way, following several instances of stress.

Researchers now have a new tool to estimate the impact of stress and treatment on the aging status of retinal tissue, which has made these new discoveries possible.

“In addition to measuring vision decline and some structural changes due to stress and potential treatment, we can now measure the epigenetic age of retinal tissue and use it to find the optimal strategy to prevent vision loss in aging,” said Skowronska-Krawczyk.

Our understanding of molecular impact of aging on response to stress in retina is very limited; therefore, we developed a new mouse model to approach this question experimentally

We demonstrate that ocular hypertension activates a stress response that is similar to natural aging and involves activation of inflammation and senescence